The cause of death has not yet been revealed.
Mendel's first foray into television came as a student, working as a production assistant on All My Children and Loving during his summer breaks. He later worked as a P.A. on shows like Broadcast News and films like Big and Jerry Maguire.
Mendel then worked on The Tracey Ullman Show, where The Simpsons began as a recurring segment, going on to serve as producer of the standalone show for 207 episodes.
During his 10-season run with The Simpsons, Mendel won the Emmy for Outstanding Animated Program three times for "Lisa's Wedding," "Homer's Phobia" and "Trash of the Titans."
He joined Rick and Morty in 2013, picking up a fourth Emmy for the episode "Pickle Rick" in 2018.
A number of Mendel's colleagues from The Simpsons and Rick and Morty have paid tribute to the producer on social media. See some of the messages below.
My friend, partner, and line producer Mike Mendel passed away. I am devastated. My heart breaks for his family. I don't know what I'm going to do without you by my side Mike. I'm destroyed.— Justin Roiland (@JustinRoiland) September 23, 2019
My friend and boss, Mike Mendel, died yesterday. I've worked with Mike on and off for almost 13 years. He was loyal, funny, grumpy and a Vikings fan. I loved him anyway. He will be so missed. https://t.co/U0KzcyRg7b— ruth (@rutlamb11) September 24, 2019
RIP Mike Mendel, Producer on Rick and Morty AND The Simpsons.— TRAFON (@RiseFallNick) September 24, 2019
54 is way too young to go. Thank you for helping make something amazing, your legacy will live in in the hearts and minds of many, on top of the influence you have passed down, forever. pic.twitter.com/7oooE3tBUO